Advances in Clinical Chemistry  Overview of Laboratory Testing and Clinical Presentations of Complement Deficiencies and Dysregulation A. Frazer-Abel*, L. Sepiashvili†, M.M. Mbughuni†, M.A.V. Willrich†, 


Comparison of chromogenic and ELISA functional C1 inhibitor tests in diagnosing hereditary angioedema. Li HH, Busse P, Lumry WR, Frazer-Abel A, Levy H, Steele T, Dayno J, Riedl M.


J Allergy Clin Immunol Pract. 2015 Mar-Apr;3(2):200-5. doi: 10.1016/j.jaip.2014.08.002. Epub 2014 Oct 11. PMID:25609336

A healthy female with C3 hypocomplementemia and C3 Nephritic Factor. Egan M, Sullivan K, Frazer-Abel A, Cunningham-Rundles C. Clin Immunol. 2016 Jun 2;169:14-15. 


Complement analysis 2016: Clinical indications, laboratory diagnostics and quality control. Prohászka Z, Nilsson B, Frazer-Abel A, Kirschfink M. Immunobiology. 2016 Nov;221(11):1247-58.


Thurman JM, Marians R, Emlen W, Wood S, Smith C, Akana H, Holers VM, Lesser M, Kline M, Hoffman C, Christen E, Trachtman H. Alternative pathway of complement in children with diarrhea-associated hemolytic uremic syndrome. Clin J Am Soc Nephrol. 2009 Dec;4(12):1920-4. PMCID2798880. 


Thurman JM, Wong M, Frazer-Abel A, Giclas PC, Radeva MK, Gipson DS, Kaskel F, Friedman A, Moxey-Mims MM, Vento SM, Trachtman H. Complement Activation in Patients with Focal Segmental Glomerulosclerosis. PLoS One. 2015, Sep 3;10(9):e0136558. PMCID: PMC4559462. 


Update on laboratory tests for the diagnosis and differentiation of hereditary angioedema and acquired angioedema. Frazer-Abel A, Giclas PC. Allergy Asthma Proc. 2011 Sep-Oct;32 Suppl 1:S17-21.


Serkova NJ, Renner B, Larsen BA, Stoldt CR, Hasebroock KM, Bradshaw-Pierce EL, Holers VM, and Thurman JM. Targeted Iron Oxide Nanoparticles for Molecular MR Imaging of Renal Inflammation in Mice. Radiology 2010. May;255(2):517-26.


Sargsyan SA, Serkova NJ, Renner B, Hasebroock KM, Larsen B, Stoldt C, Mcfann K, Pickering MC, Thurman JM. MRI-based detection of glomerular complement C3 fragments as a biomarker of lupus nephritis. Kidney International. 2012 Jan;81(2):152-9. PMCID3375901.    


Mechanistic understanding for the greater sensitivity of monkeys to antisense oligonucleotide-mediated complement activation compared with humans. Shen L, Frazer-Abel A, Reynolds PR, Giclas PC, Chappell A, Pangburn MK, Younis H, Henry SP. J Pharmacol Exp Ther. 2014 Dec;351(3):709-17. doi: 10.1124/jpet.114.219378. Epub 2014 Oct 9.

PMID: 25301170


A pilot study to assess inflammatory biomarker changes when raltegravir is added to a virologically suppressive HAART regimen in HIV-1-infected patients with limited immunological responses.

Lichtenstein KA, Armon C, Nagabhushanam V, Efaw BJ, Frazer-Abel A, Hiserote ME, Alam R.

Antivir Ther. 2012;17(7):1301-9. doi: 10.3851/IMP2350. Epub 2012 Sep 5.

PMID: 22948290


Complement Activation in Patients with Focal Segmental Glomerulosclerosis.

Thurman JM, Wong M, Renner B, Frazer-Abel A, Giclas PC, Joy MS, Jalal D, Radeva MK, Gassman J, Gipson DS, Kaskel F, Friedman A, Trachtman H. PLoS One. 2015 Sep 3;10(9):e0136558. doi: 10.1371/journal.pone.0136558. eCollection 2015.