Publications
Biomarkers in the Management of Complement-Mediated Kidney Diseases in the Era of Complement Therapeutics. Rizk, Dana V.; Dixon, Bradley P.; Chan, Melvin; Cook, H. Terence; Frazer-Abel, Ashley; Tang, Sydney C.W. . Clinical Journal of the American Society of Nephrology ():10.2215/CJN.0000000967, November 25, 2025
Genetic mapping of complement system proteins for islet autoimmunity in children with high risk of T1D. Hu, X., Webb-Robertson, BJ.M., Parikh, H.M. et al. Commun Biol 8, 1366 (2025).
Dynamic Risk of Systemic Complement Activation With Time to Progression to Advanced Age-Related Macular Degeneration. Lynch AM, Grove NC, Wagner BD, Palestine AG, Holers VM, Frazer-Abel AA, Gnanaraj R, Lisker-Cervantes A, Patnaik JL, de Carlo Forest TE, Auer EA, McReynolds AJ, Mathias MT, Manoharan N, Rodriquez De Cordoba S, Mandava N. JAMA Ophthalmol. 2025 Aug
Autoantibodies reactive with glomerular endothelial cells and podocytes in patients with membranous nephropathy. Petr V, Purohit S, Poppelaars F, Renner B, Laskowski J, Whelan R, Kulik L, Kendrick J, Frazer-Abel A, et al. Journal of Translational Autoimmunity V12, June 2026, 100342
Inhibiting the alternative pathway of complement by reducing systemic complement factor B: Randomized, double-blind, placebo-controlled phase 1 studies with Sefaxersen. McCaleb ML, Hughes SG, Grossman TR, Frazer-Abel A, Jung B, Yin L, Henry SP, Monia BP, Schneider E, Geary R, Brice GT. Immunobiology. 2025 Mar;230(2):152876
Genome-wide mapping of complement system proteins for islet autoimmunity in the DAISY and TEDDY children. Hu X, Webb-Robertson BM, Parikh HM, Nakayasu ES, Onengut-Gumuscu S, Chen WM, Frazer-Abel A, Metz TO, Rich SS, Rewers MJ, Manichaikul A. Res Sq [Preprint]. 2025 Feb
The role of complement in kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. Vivarelli M, Barratt J, Beck LH Jr, Fakhouri F, Gale DP, Goicoechea de Jorge E, Mosca M, Noris M, Pickering MC, Susztak K, Thurman JM, Cheung M, King JM, Jadoul M, Winkelmayer WC, Smith RJH; for Conference Participants. Kidney Int. 2024 Sep;106(3):369-391
Utility of factor D and other alternative complement factors as biomarkers in systemic sclerosis-associated pulmonary arterial hypertension (SSc-PAH). Petrow E, Feng C, Frazer-Abel A, Marangoni RG, Lutz K, Nichols WC, Holers VM, Ritchlin C, White RJ 3rd, Korman BD. Semin Arthritis Rheum. 2024 Dec;69:152554
Functional similarity of ABP 959 and eculizumab in simulated serum models of a HUS and NMOSD. Helen J. McBride, Ashley Frazer‑Abel, Sandra Thiemann, Sonya G. Lehto, Katariina M. Hutterer, Jennifer Liu. Published October 2023
Systematic review of type 1 diabetes biomarkers reveals regulation in circulating proteins related to complement, lipid metabolism, and immune response. Sarkar S, Elliott EC, Henry HR, Ludovico ID, Melchior JT, Frazer-Abel A, Webb-Robertson BJ, Davidson WS, Holers VM, Rewers MJ, Metz TO, Nakayasu ES. medRxiv [Preprint]. 2023 Feb
Association of Systemic Inflammatory Factors with Progression to Advanced Age-related Macular Degeneration. Brandie D. Wagner, Jennifer L. Patnaik, Alan G. Palestine, Ashley A. Frazer-Abel, Rebecca Baldermann, V. Michael Holers, Marc T. Mathias, Naresh Mandava & Anne M. Lynch
Sex and Age-Related Differences in Complement Factors Among Patients With Intermediate Age-Related Macular Degeneration. A. Itzam Marin, Felix Poppelaars, Brandie D. Wagner, Alan G. Palestine, Jennifer L. Patnaik, V. Michael Holers, Ashley A. Frazer-Abel, et al. Transl Vis Sci Technol. 2022 May
Correlation of Complement Activation in Aqueous and Vitreous in Patients With Proliferative Diabetic Retinopathy. Jesse M. Smith, Nikhil Mandava, Vanessa Tirado-Gonzalez, Rodrigo Garcia-Santisteban, Matthew D. Geiger, Jennifer L. Patnaik, Ashley Frazer-Abel, Anne M. Lynch, et al. Transl Vis Sci Technol. 2022 Apr
Improving Clinical Trials for Anticomplement Therapies in Complement-Mediated Glomerulopathies: Report published by the National Kidney Foundation 2021. Andrew S. Bomback, et al.
Complement Activation in the Vitreous of Patients With Proliferative Diabetic Retinopathy. Nikhil Mandava, Vanessa Tirado-Gonzalez, Matthew D. Geiger, Jennifer L. Patnaik, Ashley Frazer-Abel, Anne M. Lynch, Naresh Mandava, Alan G. Palestine, V. Michael Holers, Brandie D. Wagner, Idaira Sanchez-Santos, Daniela Meizner, Hugo Quiroz-Mercado, and Jesse M. Smith. Invest Ophthalmol Vis Sci. 2020 Sep
Advances in Clinical Chemistry Overview of Laboratory Testing and Clinical Presentations of Complement Deficiencies and Dysregulation A. Frazer-Abel, L. Sepiashvili, M.M. Mbughuni, M.A.V. Willrich. Published 2016
A healthy female with C3 hypocomplementemia and C3 Nephritic Factor. Egan M, Sullivan K, Frazer-Abel A, Cunningham-Rundles C. Clin Immunol. 2016 Jun
Complement analysis 2016: Clinical indications, laboratory diagnostics and quality control. Prohászka Z, Nilsson B, Frazer-Abel A, Kirschfink M. Immunobiology. 2016 Nov
Complement Activation in Patients with Focal Segmental Glomerulosclerosis. Thurman JM, Wong M, Renner B, Frazer-Abel A, Giclas PC, Joy MS, Jalal D, Radeva MK, Gassman J, Gipson DS, Kaskel F, Friedman A, Trachtman H. PLoS One. 2015 Sep. eCollection 2015.
Mechanistic understanding for the greater sensitivity of monkeys to antisense oligonucleotide-mediated complement activation compared with humans. Shen L, Frazer-Abel A, Reynolds PR, Giclas PC, Chappell A, Pangburn MK, Younis H, Henry SP. J Pharmacol Exp Ther. 2014 Dec. Epub 2014 Oct 9.
Comparison of chromogenic and ELISA functional C1 inhibitor tests in diagnosing hereditary angioedema. Li HH, Busse P, Lumry WR, Frazer-Abel A, Levy H, Steele T, Dayno J, Riedl M. Published 2014 by American Academy of Allergy, Asthma & Immunology.
MRI-based detection of glomerular complement C3 fragments as a biomarker of lupus nephritis. Sargsyan SA, Serkova NJ, Renner B, Hasebroock KM, Larsen B, Stoldt C, Mcfann K, Pickering MC, Thurman JM. Kidney International. 2012 Jan
A pilot study to assess inflammatory biomarker changes when raltegravir is added to a virologically suppressive HAART regimen in HIV-1-infected patients with limited immunological responses. Lichtenstein KA, Armon C, Nagabhushanam V, Efaw BJ, Frazer-Abel A, Hiserote ME, Alam R. Antivir Ther. 2012; Epub 2012 Sep 5.
Update on laboratory tests for the diagnosis and differentiation of hereditary angioedema and acquired angioedema. Frazer-Abel A, Giclas PC. Allergy Asthma Proc. 2011 Sep-Oct.
Targeted Iron Oxide Nanoparticles for Molecular MR Imaging of Renal Inflammation in Mice. Serkova NJ, Renner B, Larsen BA, Stoldt CR, Hasebroock KM, Bradshaw-Pierce EL, Holers VM, and Thurman JM. Radiology 2010. May
Alternative pathway of complement in children with diarrhea-associated hemolytic uremic syndrome. Thurman JM, Marians R, Emlen W, Wood S, Smith C, Akana H, Holers VM, Lesser M, Kline M, Hoffman C, Christen E, Trachtman H. Clin J Am Soc Nephrol. 2009 Dec
Posters